The 2021/22 UEFA Europa League knockout round play-off draw took place on 13 December at the House of European Football in Nyon, Switzerland.

Who will face who in the Europa League knockout round play-offs?

First legs: 17 February

18:45 CET
Barcelona (ESP) vs Napoli (ITA)
Zenit (RUS) vs Real Betis (ESP)
Dortmund (GER) vs Rangers (SCO)
Sheriff (MDA) vs Braga (POR)

21:00 CET
Sevilla (ESP) vs Dinamo Zagreb (CRO)
Atalanta (ITA) vs Olympiacos (GRE)
Leipzig (GER) vs Real Sociedad (ESP)
Porto (POR) vs Lazio (ITA)

Second legs: 24 February

18:45 CET
Dinamo Zagreb (CRO) vs Sevilla (ESP)
Olympiacos (GRE) vs Atalanta (ITA)
Real Sociedad (ESP) vs Leipzig (GER)
Lazio (ITA) vs Porto (POR)

21:00 CET
Napoli (ITA) vs Barcelona (ESP)
Real Betis (ESP) vs Zenit (RUS)
Rangers (SCO) vs Dortmund (GER)
Braga (POR) vs Sheriff (MDA)

What is the Europa League knockout round play-off stage?

The UEFA Europa League knockout round play-offs have been introduced for the first time this season. There are 16 teams involved: the eight runners-up from the UEFA Europa League group stage and the eight third-placed teams from the UEFA Champions League group stage.

The winners of the eight play-off ties advance to the UEFA Europa League round of 16 (the eight group winners have already qualified for this); the eight play-off losers will no longer be involved in 2021/22 European competition.

Which teams were seeded in the Europa League knockout round play-off draw?

There were 16 teams in the draw: the eight runners-up from the UEFA Europa League group stage were seeded; the eight third-placed teams from the UEFA Champions League group stage were unseeded.

Seeded teams
Real Betis (ESP)
Braga (POR)
Dinamo Zagreb (CRO)
Lazio (ITA)
Napoli (ITA)
Olympiacos (GRE)
Rangers (SCO)
Real Sociedad (ESP)

Unseeded teams
Atalanta (ITA)
Barcelona (ESP)
Dortmund (GER)
Leipzig (GER)
Porto (POR)
Sevilla (ESP)
Sheriff (MDA)
Zenit (RUS)

Could teams from the same country face each other in the UEFA Europa League knockout round play-offs?

No side could face another team from the same national association.