Round of 16 first leg facts and figures

• Real Madrid CF's win at FC Schalke 04 was their tenth in a row in the UEFA Champions League, matching the all-time competition record set between April and November 2013 by FC Bayern München.

• It was also the Spanish team's fifth successive away win – two short of the competition high, held jointly by Bayern and AFC Ajax.

• Madrid are appearing in the knockout phase of the UEFA Champions League for a record 19th time. They have never failed to progress from the group stage and are currently on a record run of 18 consecutive knockout phase appearances. The next best-placed clubs in that category are Arsenal FC (12) and FC Barcelona (11), both of whose runs are also ongoing.

• Barcelona's 2-1 victory at Manchester City FC came in their 200th UEFA Champions League match. They are just the third side to have reached that milestone – after Manchester United FC (200) and Real Madrid (207).

• The goal scored by City's Sergio Agüero in Manchester was also the 200th Barcelona have conceded in the competition. Only Madrid (224) have let in more.

• City's reverse against Barcelona means they have now lost more UEFA Champions League games than they have won (10 wins; 11 defeats). Three of the other round of 16 participants also have a negative balance sheet – Bayer 04 Leverkusen (31; 34), FC Shakhtar Donetsk (25; 29) and FC Basel 1893 (14; 20) – while Schalke (22; 22) will join them should they lose their second leg in Madrid.

• In taking the field against Shakhtar Donetsk in Lviv, Bayern's Xabi Alonso became the 25th player to register 100 UEFA Champions League outings.

Barcelona marked their 200th UEFA Champions League match in style©Getty Images

• The Spanish midfielder marred the occasion, however, by receiving a red card, the 15th shown to a Bayern player in the competition. Just two teams – Juventus (20) and FC Internazionale Milano (17) – have picked up more.

• There were landmark goals on matchday seven for two Argentinian strikers as Agüero took his all-time UEFA Champions League haul to 20 (the 38th player to achieve that total) and Carlos Tévez, with his strike for Juventus against Borussia Dortmund, lifted his tally to ten (the 125th to get to double figures).

• History suggests that elimination for Schalke, Manchester City and Arsenal is imminent as only two sides have ever won a UEFA Champions League knockout phase tie after losing the first leg at home. Indeed, new ground will have to be broken if any of them is to join that select band as no club has ever advanced after conceding more than one goal in a first-leg home defeat. In both of those previous comebacks – Ajax against Panathinaikos FC in the 1995/96 semi-final and Internazionale against Bayern in the 2010/11 round of 16 – the first-leg result was 0-1.